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Intravenous injection of phenobarbital has the ability to cause induction excitement in several species of animal and adequate sedation should be applied if deemed necessary by the veterinary surgeon. Measures should be taken to avoid perivascular administration (e.g. by using intravenous catheter).
– The intraperitoneal route of administration may cause a prolonged onset of action with an increased risk of induction excitement. Intraperitoneal administration must only be used following appropriate sedation. Measures should be taken to avoid administration into the spleen or organs/tissue with low capacity for absorption. This route of administration is only suitable for small animals.
A non-sterile solution containing phenobarbital sodium and phenytoin sodium as the active ingredients. Rhodamine B, a bluish-red fluorescent dye, is included in the formulation to help distinguish it from parental drugs intended for therapeutic use. Although the solution is not sterile, benzyl alcohol, a bacteriostat, is included to retard the growth of microorganisms.Buy Euthasol Euthanasia Solution 400mgml 250ml
Each mL contains: Active ingredients: 390 mg pentobarbital sodium (barbituric acid derivative), 50 mg phenytoin sodium; Inactive ingredients: 10% ethyl alcohol, 18% propylene glycol, 0.003688 mg rhodamine B, 2% benzyl alcohol (preservative), water for injection q.s. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH.
ACTIONS EUTHASOL: Euthasol Euthanasia Solution 400mg/ml (250ml) Solution (phenobarbital sodium and phenytoin sodium) contains two active ingredients which are chemically compatible but pharmacologic-ally different. Each ingredient acts in such a manner so as to cause humane, painless, and rapid euthanasia. Euthanasia is due to cerebral death in conjunction with respiratory arrest and circulatory collapse. Cerebral death occurs prior to the cessation of cardiac activity.
When administered intravenously, phenobarbital sodium produces rapid anaesthetic action. There is a smooth and rapid onset of unconsciousness. At the lethal dose, there is depression of vital medullary respiratory and vasomotor centres.
When administered intravenously, phenytoin sodium produces toxic signs of cardiovascular collapse and/or central nervous system depression. Hypo-tension occurs when the drug is administered rapidly.
Pharmacodynamic Activity The sequence of events leading to humane, painless, and rapid euthanasia following intravenous injection of Euthasol Euthanasia Solution 400mg/ml (250ml) is similar to that following intravenous injection of pentobarbital sodium, or other barbituric acid derivatives. Within seconds, unconsciousness is induced with simultaneous collapse of the dog. This stage rapidly progresses to deep anesthesia with concomitant reduction in the blood pressure. A few seconds later, breathing stops, due to depression of the medullary respiratory center; encephalographic activity becomes isoelectric, indicating cerebral death; and then cardiac activity ceases.
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